L-Glutamine: The Game Changer in Gut Health You Should Know About

The gut, often dubbed our 'second brain', plays a critical role in our overall well-being. It's entrusted with a variety of tasks, from absorbing nutrients to shaping our immune response. One supplement making significant strides in gut health is L-Glutamine. This prevalent amino acid comes loaded with numerous benefits, notably in bolstering our gut barriers and easing gut inflammation. Let's delve into how L-Glutamine is reshaping our understanding of gut health.

L-Glutamine: The Supercharger of Gut Health

L-Glutamine is the most abundant amino acid in our bloodstream, powering numerous biological processes such as protein synthesis, kidney acid-base balance, and cell energy (Sido et al., 2006). However, its most significant contribution lies in gut health. Serving as a primary energy source for the gut lining cells, L-Glutamine is indispensable for maintaining a healthy gut barrier.

The Importance of Tight Junctions in Gut Health and How L-Glutamine Helps

Tight junctions serve as security guards for your gut. These protein structures seal the gaps between cells lining your gut, preventing harmful substances from leaking into the bloodstream. When these junctions are compromised—a condition often referred to as 'leaky gut'—it can lead to health complications such as food sensitivities, inflammatory bowel disease (IBD), and increased gut inflammation.

L-Glutamine steps in to fortify these tight junctions. Studies indicate that L-Glutamine supplementation bolsters the expression of tight junction proteins, thus improving gut barrier function and reducing the risk of 'leaky gut' (Li & Neu, 2004). In fact, in patients with Crohn's disease, a type of IBD, L-Glutamine supplementation has been shown to improve intestinal barrier function (Benjamin et al., 2012).

Combating Gut Inflammation: The Anti-Inflammatory Effects of L-Glutamine

L-Glutamine plays another pivotal role by showcasing significant anti-inflammatory effects on the gut. When L-Glutamine is depleted, gut permeability increases, and inflammatory responses heighten. On the contrary, supplementation with L-Glutamine has been shown to inhibit inflammation, hinting at its potential role in managing conditions like IBD (Zuhl et al., 2015).

"DAYLY Gut Health: Your All-in-One Solution for Optimal Gut Health

When it comes to aiding your gut health journey, you can count on DAYLY Gut Health. This 4-in-1 gut health supplement not only contains L-Glutamine but also houses other gut health-boosting ingredients designed to relieve pesky symptoms like bloating, gas and oh-so-fun toilet troubles. It's your all-in-one companion for a healthier gut.

The team at DAYLY has thoughtfully formulated the supplement with four key components that each play a unique role in maintaining and enhancing gut health:

  1. Amino Acids and Amino Sugars: DAYLY not only contains L-Glutamine, but also N-acetyl D-glucosamine which supports the health of the gut lining.

  2. Polyphenols: DAYLY Gut Health contains a potent blend of polyphenols from sources such as curcumin and pomegranate peel. These plant compounds are known for their anti-inflammatory properties and their ability to help balance gut microbiota, leading to improved gut health.

  3. Sunfiber: A clinically proven prebiotic fibre, with over 170 scientific studies, Sunfiber promotes regular bowel movements and fosters the growth of beneficial gut bacteria, aiding in overall digestive health. 

  4. Mucus-Producing Herbs: DAYLY contains a blend of mucus-producing herbs, including marshmallow root, slippery elm, and DGL licorice, designed to soothe the gut lining and promote gut barrier integrity, further enhancing its gut health-supporting benefits.

Not only is DAYLY Gut Health a powerhouse of essential ingredients, but it's also designed with user convenience in mind. Each bottle comes with 30 servings of easy-to-use powder form, making it simple to incorporate into your daily routine. You can mix it into your favourite beverage, smoothie, or even food.

In terms of safety and quality, DAYLY Gut Health stands tall. It's gluten-free, dairy-free, and non-GMO. It's manufactured in Australia in a GMP-certified facility, ensuring that each batch meets high-quality standards, and it’s also banned substance tested!

So, what have we learned? L-Glutamine, a potent and versatile amino acid, plays a pivotal role in safeguarding our gut health. From reinforcing the crucial tight junctions, which protect us from undesirable 'leaky gut' to mitigating inflammation, L-Glutamine has proven to be a vital player in promoting optimal gut health. Coupled with N-Acetyl D-Glucosamine, Sunfiber, polyphenols, and beneficial mucus-producing herbs, our approach to maintaining gut health could be significantly elevated.


Benjamin, J., Makharia, G., Ahuja, V., Rajan, K. D., Kalaivani, M., Gupta, S. D., ... & Joshi, Y. K. (2012). Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. Digestive Diseases and Sciences, 57(4), 1000-1012.

Kim, M. H., & Kim, H. (2017). The roles of glutamine in the intestine and its implication in intestinal diseases. International journal of molecular sciences, 18(5), 1051.

Li, N., & Neu, J. (2009). Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells. The Journal of Nutrition, 139(4), 710-714.

Zuhl, M., Dokladny, K., Mermier, C., Schneider, S., Salgado, R., & Moseley, P. (2015). The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress and Chaperones, 20(1), 85-93.

Written by Clare Gibson 

Gut Health Nutritionist